[HTML][HTML] IFN-γ increases susceptibility to influenza A infection through suppression of group II innate lymphoid cells
Increased levels of interferon-γ (IFN-γ) are routinely observed in the respiratory tract
following influenza virus infection, yet its potential role remains unclear. We now
demonstrate that influenza-induced IFN-γ restricts protective innate lymphoid cell group II
(ILC2) function in the lung following challenge with the pandemic H1N1 A/CA/04/2009
(CA04) influenza virus. Specifically, IFN-γ deficiency resulted in enhanced ILC2 activity,
characterized by increased production of interleukin (IL)-5 and amphiregulin, and improved …
following influenza virus infection, yet its potential role remains unclear. We now
demonstrate that influenza-induced IFN-γ restricts protective innate lymphoid cell group II
(ILC2) function in the lung following challenge with the pandemic H1N1 A/CA/04/2009
(CA04) influenza virus. Specifically, IFN-γ deficiency resulted in enhanced ILC2 activity,
characterized by increased production of interleukin (IL)-5 and amphiregulin, and improved …