The immunoprotective activity of interleukin-33 in mouse model of cecal ligation and puncture-induced sepsis
S Li, FX Zhu, XJ Zhao, YZ An - Immunology letters, 2016 - Elsevier
Lymphocyte apoptosis plays a pivotal role in sepsis-induced immunosuppression and is the
primary cause of high mortality rates. Interleukin-33 is a member of the interleukin-1 family
that is involved in the polarization of T cells toward a T helper 2-cell phenotype and may
regulate apoptotic cell death. The objective of the present study was to assess the effects of
interleukin-33 on T lymphocyte apoptosis in sepsis and determine the mechanisms involved.
Sepsis was induced in C57BL/6 mice via a cecal ligation and puncture. Mice were infused …
primary cause of high mortality rates. Interleukin-33 is a member of the interleukin-1 family
that is involved in the polarization of T cells toward a T helper 2-cell phenotype and may
regulate apoptotic cell death. The objective of the present study was to assess the effects of
interleukin-33 on T lymphocyte apoptosis in sepsis and determine the mechanisms involved.
Sepsis was induced in C57BL/6 mice via a cecal ligation and puncture. Mice were infused …
