[HTML][HTML] Factors affecting human T cell engraftment, trafficking, and associated xenogeneic graft-vs-host disease in NOD/SCID β2mnull mice
B Nervi, MP Rettig, JK Ritchey, HL Wang, G Bauer… - Experimental …, 2007 - Elsevier
OBJECTIVE: Graft-vs-host disease (GVHD) is the major cause of morbidity and mortality
after allogeneic hematopoietic stem cell transplantation. Models of immunodeficient mice
that consistently and efficiently reconstitute with xenoreactive human T cells would be a
valuable tool for the in vivo study of GVHD, as well as other human immune responses.
MATERIALS AND METHODS: We developed a consistent and sensitive model of human
GVHD by retro-orbitally injecting purified human T cells into sublethally irradiated nonobese …
after allogeneic hematopoietic stem cell transplantation. Models of immunodeficient mice
that consistently and efficiently reconstitute with xenoreactive human T cells would be a
valuable tool for the in vivo study of GVHD, as well as other human immune responses.
MATERIALS AND METHODS: We developed a consistent and sensitive model of human
GVHD by retro-orbitally injecting purified human T cells into sublethally irradiated nonobese …
