Antibody humanization methods–a review and update
Biotechnology and Genetic Engineering Reviews, 2013•Taylor & Francis
This article reviews recent advances achieved during recent years on various aspects of
antibody humanization theories and techniques. Common methods for producing
humanized antibodies including framework-homology-based humanization, germline
humanization, complementary determining regions (CDR)-homology-based humanization
and specificity determining residues (SDR) grafting, as well as advantages and
disadvantages of each of these methods and their applications are discussed.
antibody humanization theories and techniques. Common methods for producing
humanized antibodies including framework-homology-based humanization, germline
humanization, complementary determining regions (CDR)-homology-based humanization
and specificity determining residues (SDR) grafting, as well as advantages and
disadvantages of each of these methods and their applications are discussed.
This article reviews recent advances achieved during recent years on various aspects of antibody humanization theories and techniques. Common methods for producing humanized antibodies including framework-homology-based humanization, germline humanization, complementary determining regions (CDR)-homology-based humanization and specificity determining residues (SDR) grafting, as well as advantages and disadvantages of each of these methods and their applications are discussed.
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