[PDF][PDF] Amino acid sensing by mTORC1: intracellular transporters mark the spot
DCI Goberdhan, C Wilson, AL Harris - Cell metabolism, 2016 - cell.com
DCI Goberdhan, C Wilson, AL Harris
Cell metabolism, 2016•cell.comCell metabolism and growth are matched to nutrient availability via the amino-acid-regulated
mechanistic target of rapamycin complex 1 (mTORC1). Transporters have emerged as
important amino acid sensors controlling mTOR recruitment and activation at the surface of
multiple intracellular compartments. Classically, this has involved late endosomes and
lysosomes, but now, in a recent twist, also the Golgi apparatus. Here we propose a model in
which specific amino acids in assorted compartments activate different mTORC1 complexes …
mechanistic target of rapamycin complex 1 (mTORC1). Transporters have emerged as
important amino acid sensors controlling mTOR recruitment and activation at the surface of
multiple intracellular compartments. Classically, this has involved late endosomes and
lysosomes, but now, in a recent twist, also the Golgi apparatus. Here we propose a model in
which specific amino acids in assorted compartments activate different mTORC1 complexes …
Cell metabolism and growth are matched to nutrient availability via the amino-acid-regulated mechanistic target of rapamycin complex 1 (mTORC1). Transporters have emerged as important amino acid sensors controlling mTOR recruitment and activation at the surface of multiple intracellular compartments. Classically, this has involved late endosomes and lysosomes, but now, in a recent twist, also the Golgi apparatus. Here we propose a model in which specific amino acids in assorted compartments activate different mTORC1 complexes, which may have distinct drug sensitivities and functions. We will discuss the implications of this for mTORC1 function in health and disease.
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