[PDF][PDF] CD4+ CD3− accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells

MY Kim, FMC Gaspal, HE Wiggett, FM McConnell… - Immunity, 2003 - cell.com
MY Kim, FMC Gaspal, HE Wiggett, FM McConnell, A Gulbranson-Judge, C Raykundalia…
Immunity, 2003cell.com
In this report we identify an accessory cell that interacts with primed and memory T cells at
sites where they collaborate with B cells. These cells are distinguished from conventional
dendritic cells by their lack of response to Flt3 ligand and their inability to process antigen.
Unlike dendritic cells, the CD4+ CD3− cells have little CD80 or CD86 expression but do
express high levels of the TNF ligands, OX40 ligand and CD30 ligand. We show that Th2-
primed cells express the receptors for these TNF ligands and preferentially survive when …
Abstract
In this report we identify an accessory cell that interacts with primed and memory T cells at sites where they collaborate with B cells. These cells are distinguished from conventional dendritic cells by their lack of response to Flt3 ligand and their inability to process antigen. Unlike dendritic cells, the CD4+CD3 cells have little CD80 or CD86 expression but do express high levels of the TNF ligands, OX40 ligand and CD30 ligand. We show that Th2-primed cells express the receptors for these TNF ligands and preferentially survive when cocultured with these cells. Furthermore, we show that the preferential survival of OX40+ T cells and support of memory T cell help for B cells are linked to their association with CD4+CD3 cells in vivo.
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