Altered respiratory epithelial cell cytokine production in cystic fibrosis
TL Bonfield, MW Konstan, M Berger - Journal of Allergy and Clinical …, 1999 - Elsevier
Background: Reports that lung inflammation in patients with cystic fibrosis (CF) might
precede infection raise the possibility that the excessive inflammatory response in lungs of
patients with CF might be directly related to defects in epithelial cell cystic fibrosis
transmembrane regulator. Objective: We sought to determine the relationship of epithelial
cell cytokine production to CF lung disease. Methods: Immunofluorescence and cultures of
freshly obtained bronchial epithelial cells and ELISA for IL-10, IL-8, and IL-6 were used to …
precede infection raise the possibility that the excessive inflammatory response in lungs of
patients with CF might be directly related to defects in epithelial cell cystic fibrosis
transmembrane regulator. Objective: We sought to determine the relationship of epithelial
cell cytokine production to CF lung disease. Methods: Immunofluorescence and cultures of
freshly obtained bronchial epithelial cells and ELISA for IL-10, IL-8, and IL-6 were used to …