[HTML][HTML] The syntaxin 4 N terminus regulates its basolateral targeting by munc18c-dependent and-independent mechanisms
J Torres, HM Funk, MMP Zegers… - Journal of Biological …, 2011 - ASBMB
To generate and maintain epithelial cell polarity, specific sorting of proteins into vesicles
destined for the apical and basolateral domain is required. Syntaxin 3 and 4 are apical and
basolateral SNARE proteins important for the specificity of vesicle fusion at the apical and
basolateral plasma membrane domains, respectively, but how these proteins are specifically
targeted to these domains themselves is unclear. Munc18/SM proteins are potential
regulators of this process. Like syntaxins, they are crucial for exocytosis and vesicle fusion …
destined for the apical and basolateral domain is required. Syntaxin 3 and 4 are apical and
basolateral SNARE proteins important for the specificity of vesicle fusion at the apical and
basolateral plasma membrane domains, respectively, but how these proteins are specifically
targeted to these domains themselves is unclear. Munc18/SM proteins are potential
regulators of this process. Like syntaxins, they are crucial for exocytosis and vesicle fusion …