[HTML][HTML] Munc18-1 regulates first-phase insulin release by promoting granule docking to multiple syntaxin isoforms
Background: Munc18-1 is expressed in islet β-cells, but its functional requirement remains
unknown. Results: Munc18-1 knock-out mice have impaired glucose tolerance and first-
phase insulin release defects. Munc18-1 overexpression enhances human islet insulin
release and increases SNARE complex formation. Conclusion: Munc18-1 is required in
insulin exocytosis for facilitating SNARE assembly using multiple syntaxin isoforms.
Significance: Increased Munc18-1 in human islets enhances β-cell function.
unknown. Results: Munc18-1 knock-out mice have impaired glucose tolerance and first-
phase insulin release defects. Munc18-1 overexpression enhances human islet insulin
release and increases SNARE complex formation. Conclusion: Munc18-1 is required in
insulin exocytosis for facilitating SNARE assembly using multiple syntaxin isoforms.
Significance: Increased Munc18-1 in human islets enhances β-cell function.