A new primate model for multiple sclerosis in the common marmoset

BA't Hart, M Van Meurs, HPM Brok, L Massacesi… - Immunology today, 2000 - cell.com
BA't Hart, M Van Meurs, HPM Brok, L Massacesi, J Bauer, L Boon, RE Bontrop, JD Laman
Immunology today, 2000cell.com
Experimental autoimmune encephalomyelitis (EAE) in outbred marmoset monkeys
(Callithrix jacchus) is a recently developed nonhuman primate model of multiple sclerosis.
Here, Bert 't Hart and colleagues compare this model to EAE in rhesus monkeys,
highlighting autoimmune mechanisms in CNS inflammation and demyelination, including
the role of major histocompatibility complex restriction and preclinical evaluation of
innovative immunotherapies.
Abstract
Experimental autoimmune encephalomyelitis (EAE) in outbred marmoset monkeys (Callithrix jacchus) is a recently developed nonhuman primate model of multiple sclerosis. Here, Bert ‘t Hart and colleagues compare this model to EAE in rhesus monkeys, highlighting autoimmune mechanisms in CNS inflammation and demyelination, including the role of major histocompatibility complex restriction and preclinical evaluation of innovative immunotherapies.
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