[HTML][HTML] The Role of the α3 (VI) Chain in Collagen VI Assembly: Expression of an α3 (vi) chain lacking n-terminal modules n10–n7 restores collagen vi assembly …
SR Lamandé, E Sigalas, TC Pan, ML Chu… - Journal of Biological …, 1998 - ASBMB
Collagen VI is a microfibrillar protein found in the extracellular matrix of virtually all
connective tissues. Three genetically distinct subunits, the α1 (VI), α2 (VI), and α3 (VI)
chains, associate intracellularly to form triple-helical monomers, which then assemble into
disulfide-bonded dimers and tetramers before secretion. Although sequence considerations
suggest that collagen VI monomers composed of all three chains are the most stable
isoform, the precise chain composition of collagen VI remains controversial and alternative …
connective tissues. Three genetically distinct subunits, the α1 (VI), α2 (VI), and α3 (VI)
chains, associate intracellularly to form triple-helical monomers, which then assemble into
disulfide-bonded dimers and tetramers before secretion. Although sequence considerations
suggest that collagen VI monomers composed of all three chains are the most stable
isoform, the precise chain composition of collagen VI remains controversial and alternative …