[HTML][HTML] CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor …
LYW Bourguignon, PA Singleton, F Diedrich… - Journal of Biological …, 2004 - ASBMB
We have explored CD44 (a hyaluronan (HA) receptor) interaction with a Na+-H+ exchanger
(NHE1) and hyaluronidase-2 (Hyal-2) during HA-induced cellular signaling in human breast
tumor cells (MDA-MB-231 cell line). Immunological analyses demonstrate that CD44s
(standard form) and two signaling molecules (NHE1 and Hyal-2) are closely associated in a
complex in MDA-MB-231 cells. These three proteins are also significantly enriched in
cholesterol and ganglioside-containing lipid rafts, characterized as caveolin and flotillin-rich …
(NHE1) and hyaluronidase-2 (Hyal-2) during HA-induced cellular signaling in human breast
tumor cells (MDA-MB-231 cell line). Immunological analyses demonstrate that CD44s
(standard form) and two signaling molecules (NHE1 and Hyal-2) are closely associated in a
complex in MDA-MB-231 cells. These three proteins are also significantly enriched in
cholesterol and ganglioside-containing lipid rafts, characterized as caveolin and flotillin-rich …