Idiopathic intracranial hypertension: a possible complication in the natural history of advanced prostate cancer

F Valcamonico, G Arcangeli, F Consoli… - … Journal of Urology, 2014 - Wiley Online Library
F Valcamonico, G Arcangeli, F Consoli, D Nonnis, S Grisanti, E Gatti, A Berruti, V Ferrari
International Journal of Urology, 2014Wiley Online Library
Idiopathic intracranial hypertension is a variety of intracranial hypertension that is extremely
rare in men. Obesity and hypogonadism are the most important predictive factors. Etiological
hypotheses include increased central venous pressure, and various hormonal and
metabolic changes commonly found in obese patients. We described the case of an obese
man with prostate cancer who showed a consistent bodyweight increase during treatment
with taxanes and prednisone. He was hospitalized because of a severe loss of vision as a …
Abstract
Idiopathic intracranial hypertension is a variety of intracranial hypertension that is extremely rare in men. Obesity and hypogonadism are the most important predictive factors. Etiological hypotheses include increased central venous pressure, and various hormonal and metabolic changes commonly found in obese patients. We described the case of an obese man with prostate cancer who showed a consistent bodyweight increase during treatment with taxanes and prednisone. He was hospitalized because of a severe loss of vision as a consequence of idiopathic intracranial hypertension. A complete symptom remission was obtained after 3 weeks of anti‐edema therapies (steroids, acetazolamide). Castration‐resistant prostate cancer is a risk factor for idiopathic intracranial hypertension. Long‐term androgen deprivation therapy, bodyweight increase, and fluid retention during chronic steroid administration and taxane chemotherapy might favor the disease onset. This severe complication has a good outcome, and should be suspected in the presence of symptoms and signs of intracranial hypertension.
Wiley Online Library