Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis
ContextInconsistent data suggest that endogenous sex hormones may have a role in sex-
dependent etiologies of type 2 diabetes, such that hyperandrogenism may increase risk in
women while decreasing risk in men. ObjectiveTo systematically assess studies evaluating
the association of plasma levels of testosterone, sex hormone–binding globulin (SHBG), and
estradiol with risk of type 2 diabetes. Data SourcesSystematic search of EMBASE and
MEDLINE (1966-June 2005) for English-language articles using the keywords diabetes …
dependent etiologies of type 2 diabetes, such that hyperandrogenism may increase risk in
women while decreasing risk in men. ObjectiveTo systematically assess studies evaluating
the association of plasma levels of testosterone, sex hormone–binding globulin (SHBG), and
estradiol with risk of type 2 diabetes. Data SourcesSystematic search of EMBASE and
MEDLINE (1966-June 2005) for English-language articles using the keywords diabetes …