5 α-reductase activity in polycystic ovary syndrome
PM Stewart, CRW Edwards, CHL Shackleton… - The Lancet, 1990 - Elsevier
PM Stewart, CRW Edwards, CHL Shackleton, GH Beastall
The Lancet, 1990•ElsevierAbstract 11 patients with polycystic ovary syndrome (hirsutism and oligomenorrhoea), but
with no deficiency of 21-hydroxylase or 3β-hydroxysteroid dehydrogenase, had abnormal
cortisol metabolism. The high ratio of 5α to 5β cortisol metabolites in the urine is consistent
with enhanced activity of 5α-reductase. Urinary total cortisol metabolites were higher in
patients than controls. Increased 5α-reductase activity in liver and skin enhances hepatic
cortisol metabolism at the expense of androgen excess and may be the underlying …
with no deficiency of 21-hydroxylase or 3β-hydroxysteroid dehydrogenase, had abnormal
cortisol metabolism. The high ratio of 5α to 5β cortisol metabolites in the urine is consistent
with enhanced activity of 5α-reductase. Urinary total cortisol metabolites were higher in
patients than controls. Increased 5α-reductase activity in liver and skin enhances hepatic
cortisol metabolism at the expense of androgen excess and may be the underlying …
Abstract
11 patients with polycystic ovary syndrome (hirsutism and oligomenorrhoea), but with no deficiency of 21 -hydroxylase or 3β-hydroxysteroid dehydrogenase, had abnormal cortisol metabolism. The high ratio of 5α to 5β cortisol metabolites in the urine is consistent with enhanced activity of 5α-reductase. Urinary total cortisol metabolites were higher in patients than controls. Increased 5α-reductase activity in liver and skin enhances hepatic cortisol metabolism at the expense of androgen excess and may be the underlying abnormality in polycystic ovary syndrome.
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