Accumulation of cholesterol in the liver is associated with the development of non-alcoholic
steatohepatitis-related fibrosis. However, underlying mechanisms are not well understood.
The present study investigated the role of inducible nitric oxide synthase (iNOS) in
cholesterol-induced liver fibrosis by feeding wild-type (WT) and iNOS-deficient mice with
control or high-cholesterol diet (HCD) for 6 weeks. WT mice fed with HCD developed greater
liver fibrosis, compared with iNOS-deficient mice, as evident by Sirius red staining and …