The endocannabinoid system is involved in the pathogenesis of liver fibrosis. Although
many substances have been proved to reduce fibrosis in experimental models of chronic
liver injury, most of them appear to be effective only if given as a prophylactic or early
treatment. This study aimed to explore the effect of pharmacological antagonism of the
endocannabinoid cannabinoid type 1 (CB1) receptor started after the stage of full-blown
cirrhosis had been reached. Wistar-Han rats with carbon tetrachloride (CCl 4)-induced …