A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic …
MPH le Graverand, RS Clemmer, P Redifer… - Annals of the rheumatic …, 2013 - Elsevier
Objective To determine if inhibition of inducible nitric oxide synthase (iNOS) with cindunistat
hydrochloride maleate slows progression of osteoarthritis (OA) Methods This 2-year,
multinational, double-blind, placebo-controlled trial enrolled patients with symptomatic knee
OA (Kellgren and Lawrence Grade (KLG) 2 or 3). Standard OA therapies were permitted
throughout. Patients were randomly assigned to cindunistat (50 or 200 mg/day) or placebo.
Randomisation was stratified by KLG. Radiographs to assess joint space narrowing (JSN) …
hydrochloride maleate slows progression of osteoarthritis (OA) Methods This 2-year,
multinational, double-blind, placebo-controlled trial enrolled patients with symptomatic knee
OA (Kellgren and Lawrence Grade (KLG) 2 or 3). Standard OA therapies were permitted
throughout. Patients were randomly assigned to cindunistat (50 or 200 mg/day) or placebo.
Randomisation was stratified by KLG. Radiographs to assess joint space narrowing (JSN) …