Cholestatic liver injury following extra-or intrahepatic bile duct obstruction causes
nonparenchymal cell proliferation and matrix deposition leading to end-stage liver disease
and cirrhosis. In cholestatic conditions, nitric oxide (NO) is mainly produced by a hepatocyte-
inducible NO synthase (iNOS) as a result of enhanced inflow of endotoxins to the liver and
also by accumulation of bile salts in hepatocytes and subsequent hepatocellular injury. This
study was aimed to investigate the role of NO and S-nitrosothiol (SNO) homeostasis in the …