The parathyroid hormone-like peptide associated with humoral hypercalcemia of malignancy and parathyroid hormone bind to the same receptor on the plasma …
H Jüppner, AB Abou-Samra, S Uneno, WX Gu… - Journal of Biological …, 1988 - ASBMB
[Tyr36] human adenylate cyclase stimulating peptide (1-36)-NH2, an amino-terminal analog
of a tumor peptide which is associated with hypercalcemia of malignancy, and [Nle8, Nle18,
Tyr34] bovine parathyroid hormone (PTH)-(1-34)-NH2 both bind with similar affinities to
receptors on rat osteosarcoma cells, ROS 17/2.8, when either of the peptides is used as the
radioligand. Pretreatment of the cells with either peptide down-regulates available binding
sites for either radioligand and desensitizes the cAMP accumulation stimulated by either …
of a tumor peptide which is associated with hypercalcemia of malignancy, and [Nle8, Nle18,
Tyr34] bovine parathyroid hormone (PTH)-(1-34)-NH2 both bind with similar affinities to
receptors on rat osteosarcoma cells, ROS 17/2.8, when either of the peptides is used as the
radioligand. Pretreatment of the cells with either peptide down-regulates available binding
sites for either radioligand and desensitizes the cAMP accumulation stimulated by either …
