[HTML][HTML] The tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases
DR Walkinshaw, R Weist, GW Kim, L You, L Xiao… - Journal of Biological …, 2013 - ASBMB
Histone deacetylases 4 (HDAC4),-5,-7, and-9 form class IIa within the HDAC superfamily
and regulate diverse physiological and pathological cellular programs. With conserved
motifs for phosphorylation-dependent 14-3-3 binding, these deacetylases serve as novel
signal transducers that are able to modulate histone acetylation and gene expression in
response to extracellular cues. Here, we report that in a PKA-sensitive manner the tumor
suppressor kinase LKB1 acts through salt-inducible kinase 2 (SIK2) and SIK3 to promote …
and regulate diverse physiological and pathological cellular programs. With conserved
motifs for phosphorylation-dependent 14-3-3 binding, these deacetylases serve as novel
signal transducers that are able to modulate histone acetylation and gene expression in
response to extracellular cues. Here, we report that in a PKA-sensitive manner the tumor
suppressor kinase LKB1 acts through salt-inducible kinase 2 (SIK2) and SIK3 to promote …