Recombinant human interleukin 1β induces production of prostaglandins in primary human fetal astrocytes and immortalized human fetal astrocyte cultures

ET Dayton, EO Major - Journal of neuroimmunology, 1996 - Elsevier
Astrocytes play an important role in initiating and modulating inflammatory responses within
the central nervous system. Extensive studies in rodents have shown that TPA, substance P,
calcium ionophore A21387, and lipopolysaccharide (LPS) induce formation and release of
arachidonic acid metabolites which have immunoregulatory properties. To better understand
the immunopathology of brain injury, we studied the role of inflammatory cytokines such as
tumor necrosis factor α, interleukin (IL) 6, IL-2, interferon γ and IL-1β in the production of …