Maternal immune activation (MIA) model is increasingly well appreciated as a rodent model
for the environmental risk factor of various psychiatric disorders. Numerous studies have
demonstrated that MIA model is able to show face, construct, and predictive validity that are
relevant to autism and schizophrenia. To model MIA, investigators often use viral mimic
polyinosinic: polycytidylic acid (poly (I: C)) to activate the immune system in pregnant
rodents. Generally, the offspring from immune activated dam exhibit behavioral …