Localization, synthesis, and processing of surfactant protein SP-C in rat lung analyzed by epitope-specific antipeptide antibodies.
MF Beers, CY Kim, C Dodia, AB Fisher - Journal of Biological Chemistry, 1994 - ASBMB
Surfactant protein C (SP-C), a 3.7-kDa hydrophobic lung-specific protein, is synthesized and
secreted by pulmonary type II cells through proteolytic processing of a 21-kDa propeptide
(SP-C21) by currently undefined pathways. Previously, we reported the production of a
polyclonal antibody against rat SP-C21 (anti-CPROSP-C) using a synthetic peptide as the
immunizing antigen (Beers, MF, Wali, A., Eckenhoff, MEF, Feinstein, S., Fisher, JH, and
Fisher, AB (1992) Am. J. Respir. Cell. Mol. Biol. 7, 368-378). In this study, two additional …
secreted by pulmonary type II cells through proteolytic processing of a 21-kDa propeptide
(SP-C21) by currently undefined pathways. Previously, we reported the production of a
polyclonal antibody against rat SP-C21 (anti-CPROSP-C) using a synthetic peptide as the
immunizing antigen (Beers, MF, Wali, A., Eckenhoff, MEF, Feinstein, S., Fisher, JH, and
Fisher, AB (1992) Am. J. Respir. Cell. Mol. Biol. 7, 368-378). In this study, two additional …