Bimodal control of stimulated food intake by the endocannabinoid system
L Bellocchio, P Lafenêtre, A Cannich, D Cota… - Nature …, 2010 - nature.com
Nature neuroscience, 2010•nature.com
Activation of cannabinoid type-1 receptors (CB1) is universally recognized as a powerful
endogenous orexigenic signal, but the detailed underlying neuronal mechanisms are not
fully understood. Using combined genetic and pharmacological approaches in mice, we
found that ventral striatal CB1 receptors exerted a hypophagic action through inhibition of
GABAergic transmission. Conversely, brain CB1 receptors modulating excitatory
transmission mediated the well-known orexigenic effects of cannabinoids.
endogenous orexigenic signal, but the detailed underlying neuronal mechanisms are not
fully understood. Using combined genetic and pharmacological approaches in mice, we
found that ventral striatal CB1 receptors exerted a hypophagic action through inhibition of
GABAergic transmission. Conversely, brain CB1 receptors modulating excitatory
transmission mediated the well-known orexigenic effects of cannabinoids.
Abstract
Activation of cannabinoid type-1 receptors (CB1) is universally recognized as a powerful endogenous orexigenic signal, but the detailed underlying neuronal mechanisms are not fully understood. Using combined genetic and pharmacological approaches in mice, we found that ventral striatal CB1 receptors exerted a hypophagic action through inhibition of GABAergic transmission. Conversely, brain CB1 receptors modulating excitatory transmission mediated the well-known orexigenic effects of cannabinoids.
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