Ventral tegmental area cannabinoid type-1 receptors control voluntary exercise performance
BACKGROUND: We have shown that the endogenous stimulation of cannabinoid type-1
(CB1) receptors is a prerequisite for voluntary running in mice, but the precise mechanisms
through which the endocannabinoid system exerts a tonic control on running performance
remain unknown. METHODS: We analyzed the respective impacts of constitutive/conditional
CB1 receptor mutations and of CB1 receptor blockade on wheel-running performance. We
then assessed the consequences of ventral tegmental area (VTA) CB1 receptor blockade on …
(CB1) receptors is a prerequisite for voluntary running in mice, but the precise mechanisms
through which the endocannabinoid system exerts a tonic control on running performance
remain unknown. METHODS: We analyzed the respective impacts of constitutive/conditional
CB1 receptor mutations and of CB1 receptor blockade on wheel-running performance. We
then assessed the consequences of ventral tegmental area (VTA) CB1 receptor blockade on …