[HTML][HTML] Platelets in inflammation and atherogenesis

M Gawaz, H Langer, AE May - The Journal of clinical …, 2005 - Am Soc Clin Investig
M Gawaz, H Langer, AE May
The Journal of clinical investigation, 2005Am Soc Clin Investig
Platelets represent an important linkage between inflammation, thrombosis, and
atherogenesis. Inflammation is characterized by interactions among platelets, leukocytes,
and ECs. These interactions trigger autocrine and paracrine activation processes that lead
to leukocyte recruitment into the vascular wall. Platelet-induced chronic inflammatory
processes at the vascular wall result in development of atherosclerotic lesions and
atherothrombosis. This Review highlights the molecular machinery and inflammatory …
Platelets represent an important linkage between inflammation, thrombosis, and atherogenesis. Inflammation is characterized by interactions among platelets, leukocytes, and ECs. These interactions trigger autocrine and paracrine activation processes that lead to leukocyte recruitment into the vascular wall. Platelet-induced chronic inflammatory processes at the vascular wall result in development of atherosclerotic lesions and atherothrombosis. This Review highlights the molecular machinery and inflammatory pathways used by platelets to initiate and accelerate atherothrombosis.
The Journal of Clinical Investigation