[PDF][PDF] Control of regulatory T cell lineage commitment and maintenance

SZ Josefowicz, A Rudensky - Immunity, 2009 - cell.com
SZ Josefowicz, A Rudensky
Immunity, 2009cell.com
Foxp3-expressing regulatory T (Treg) cells suppress pathology mediated by immune
responses against self and foreign antigens and commensal microorganisms. Sustained
expression of the transcription factor Foxp3, a key distinguishing feature of Treg cells, is
required for their differentiation and suppressor function. In addition, Foxp3 expression
prevents deviation of Treg cells into effector T cell lineages and confers dependence of Treg
cell survival and expansion on growth factors, foremost interleukin-2, provided by activated …
Foxp3-expressing regulatory T (Treg) cells suppress pathology mediated by immune responses against self and foreign antigens and commensal microorganisms. Sustained expression of the transcription factor Foxp3, a key distinguishing feature of Treg cells, is required for their differentiation and suppressor function. In addition, Foxp3 expression prevents deviation of Treg cells into effector T cell lineages and confers dependence of Treg cell survival and expansion on growth factors, foremost interleukin-2, provided by activated effector T cells. In this review we discuss Treg cell differentiation and maintenance with a particular emphasis on molecular regulation of Foxp3 expression, arguably a key to mechanistic understanding of biology of regulatory T cells.
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