Efficient promotion of collagen antibody induced arthritis (CAIA) using four monoclonal antibodies specific for the major epitopes recognized in both collagen induced …

KS Nandakumar, R Holmdahl - Journal of immunological methods, 2005 - Elsevier
An antibody response to defined epitopes located on the triple helical portion of type II
collagen (CII) is associated with the development of collagen-induced arthritis (CIA) and
rheumatoid arthritis (RA). Monoclonal antibodies to epitopes associated with arthritis, but not
antibodies specific for epitopes not associated with arthritis, induce arthritis in mice, the so-
called collagen antibody induced arthritis (CAIA) model. We have selected monoclonal IgG
antibodies specific for four well-defined major epitopes on triple helical CII, the C1, J1, D3 …