[HTML][HTML] Anti-carbamylated protein antibodies in rheumatoid arthritis patients and their association with rheumatoid factor

MA Othman, WSW Ghazali, WZWA Hamid… - Saudi medical …, 2017 - ncbi.nlm.nih.gov
MA Othman, WSW Ghazali, WZWA Hamid, KK Wong, NK Yahya
Saudi medical journal, 2017ncbi.nlm.nih.gov
Objectives: To evaluate levels of anti-carbamylated protein (anti-CarP) antibodies in
rheumatoid arthritis (RA) patients and to determine their association with serological
parameters and disease activity. Methods: A cross-sectional study involving 105 multiethnic
RA patients (48 rheumatoid factor [RF]-positive and 57 RF-negative patients) was conducted
at Hospital Universiti Sains Malaysia, Kelantan, Malaysia, from January 2015 to February
2016. Fifty healthy controls (HCs) were included. C-reactive protein (CRP), RF, anti-cyclic …
Abstract
Objectives:
To evaluate levels of anti-carbamylated protein (anti-CarP) antibodies in rheumatoid arthritis (RA) patients and to determine their association with serological parameters and disease activity.
Methods:
A cross-sectional study involving 105 multiethnic RA patients (48 rheumatoid factor [RF]-positive and 57 RF-negative patients) was conducted at Hospital Universiti Sains Malaysia, Kelantan, Malaysia, from January 2015 to February 2016. Fifty healthy controls (HCs) were included. C-reactive protein (CRP), RF, anti-cyclic citrullinated peptide (anti-CCP) and anti-CarP antibodies were measured. A health assessment questionnaire (HAQ) was administered to the study participants and 28-joint Disease Activity Score (DAS28) were obtained.
Results:
The level of anti-CarP antibodies was significantly increased in the RA patients compared with HCs (p= 0.042). The presence of anti-CarP antibodies was significantly associated with RF (p= 0.019) and the HAQ (p= 0.010). A significant association between the presence of anti-CarP antibodies and the DAS28 was not found (p= 0.632).
Conclusion:
Our study provides further evidence that the level of anti-CarP antibodies is significantly elevated in RA patients.
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