The role of Toll-like receptor signalling in the pathogenesis of arthritis

F Brentano, D Kyburz, O Schorr, R Gay, S Gay - Cellular immunology, 2005 - Elsevier
Recent evidence highlighted the role of Toll-like receptors (TLRs) as key recognition
structures of the innate immune system. The activation of TLRs initiates the production of
inflammatory cytokines, chemokines, tissue destructive enzymes, and type I interferons. In
addition, TLR signalling plays an important role in the activation and direction of the
adaptive immune system by the upregulation of costimulatory molecules of antigen
presenting cells. Considering the important role of TLR signalling as a critical link between …