[HTML][HTML] Signaling from G Protein-coupled Receptors to c-Jun Kinase Involves βγ Subunits of Heterotrimeric G Proteins Acting on a Ras and Rac1-dependent Pathway …
OA Coso, H Teramoto, WF Simonds… - Journal of Biological …, 1996 - ASBMB
Stimulation of a variety of cell surface receptors enhances the enzymatic activity of mitogen-
activated protein kinases (MAPKs). MAPKs have been classified in three subfamilies:
extracellular signal-regulated kinases (ERKs), stress-activated protein kinases or c-Jun NH
2-terminal kinases (SAPKs/JNKs), and p38 kinase. Whereas the pathway linking cell surface
receptors to ERKs has been partially elucidated, the mechanism of activation of JNKs is still
poorly understood. Recently, we have shown that stimulation of G protein-coupled receptors …
activated protein kinases (MAPKs). MAPKs have been classified in three subfamilies:
extracellular signal-regulated kinases (ERKs), stress-activated protein kinases or c-Jun NH
2-terminal kinases (SAPKs/JNKs), and p38 kinase. Whereas the pathway linking cell surface
receptors to ERKs has been partially elucidated, the mechanism of activation of JNKs is still
poorly understood. Recently, we have shown that stimulation of G protein-coupled receptors …