IL-27 and type 2 immunity in asthmatic patients: association with severity, CXCL9, and signal transducer and activator of transcription signaling
M Xie, AT Mustovich, Y Jiang, JB Trudeau… - Journal of Allergy and …, 2015 - Elsevier
Background Severe asthma (SA) can involve both innate and type 2 cytokine–associated
adaptive immunity. Although IL-27 has been reported to potentiate TH 1 responses
(including the chemokine CXCL9) and suppress TH 2 responses, its function in asthmatic
patients is unknown. Objective We sought to evaluate IL-27 expression in human asthma
alone and in combination with type 2 immunity to determine the relationship to disease
severity and CXCL9 expression. We also sought to model these interactions in vitro in …
adaptive immunity. Although IL-27 has been reported to potentiate TH 1 responses
(including the chemokine CXCL9) and suppress TH 2 responses, its function in asthmatic
patients is unknown. Objective We sought to evaluate IL-27 expression in human asthma
alone and in combination with type 2 immunity to determine the relationship to disease
severity and CXCL9 expression. We also sought to model these interactions in vitro in …
