IgG and leukocytes: Targets of immunomodulatory α2, 6 sialic acids
MB Jones - Cellular immunology, 2018 - Elsevier
ST6Gal1 is a critical sialyltransferase enzyme that controls the addition of α2, 6-linked sialic
acids to the termini of glycans. Attachment of sialic acids to glycoproteins as a
posttranslational modification influences cellular responses, and is a well-known modifier of
immune cell behavior. ST6Gal1 activity impacts processes such as: effector functions of
immunoglobulin G via Fc sialylation, hematopoietic capacity by hematopoietic stem and
progenitor cell surface sialylation, and lymphocyte activation thresholds though CD22 …
acids to the termini of glycans. Attachment of sialic acids to glycoproteins as a
posttranslational modification influences cellular responses, and is a well-known modifier of
immune cell behavior. ST6Gal1 activity impacts processes such as: effector functions of
immunoglobulin G via Fc sialylation, hematopoietic capacity by hematopoietic stem and
progenitor cell surface sialylation, and lymphocyte activation thresholds though CD22 …