[HTML][HTML] N-Glycosylation affects the stability and barrier function of the MUC16 mucin
T Taniguchi, AM Woodward, P Magnelli… - Journal of Biological …, 2017 - ASBMB
Transmembrane mucins are highly O-glycosylated glycoproteins that coat the apical
glycocalyx on mucosal surfaces and represent the first line of cellular defense against
infection and injury. Relatively low levels of N-glycans are found on transmembrane mucins,
and their structure and function remain poorly characterized. We previously reported that
carbohydrate-dependent interactions of transmembrane mucins with galectin-3 contribute to
maintenance of the epithelial barrier at the ocular surface. Now, using MALDI-TOF mass …
glycocalyx on mucosal surfaces and represent the first line of cellular defense against
infection and injury. Relatively low levels of N-glycans are found on transmembrane mucins,
and their structure and function remain poorly characterized. We previously reported that
carbohydrate-dependent interactions of transmembrane mucins with galectin-3 contribute to
maintenance of the epithelial barrier at the ocular surface. Now, using MALDI-TOF mass …