[HTML][HTML] αB-crystallin Gene Induction and Phosphorylation by MKK6-activated p38: a potential role for αb-crystallin as a target of the p38 branch of the cardiac stress …
HE Hoover, DJ Thuerauf, JJ Martindale… - Journal of Biological …, 2000 - ASBMB
The MAPK kinase MKK6 selectively stimulates p38 MAPK and confers protection against
stress-induced apoptosis in cardiac myocytes. However, the events lying downstream of p38
that mediate this protection are unknown. The small heat shock protein, αB-crystallin, which
is expressed in only a few cell types, including cardiac myocytes, may participate in MKK6-
mediated cytoprotection. In the present study, we showed that, in cultured cardiac myocytes,
expression of MKK6 (Glu), an active form of MKK6, led to p38-dependent increases in αB …
stress-induced apoptosis in cardiac myocytes. However, the events lying downstream of p38
that mediate this protection are unknown. The small heat shock protein, αB-crystallin, which
is expressed in only a few cell types, including cardiac myocytes, may participate in MKK6-
mediated cytoprotection. In the present study, we showed that, in cultured cardiac myocytes,
expression of MKK6 (Glu), an active form of MKK6, led to p38-dependent increases in αB …