[HTML][HTML] Ushering in the cardiac role of Ubiquilin1

X Fang, C Trexler, J Chen - The Journal of clinical …, 2018 - Am Soc Clin Investig
X Fang, C Trexler, J Chen
The Journal of clinical investigation, 2018Am Soc Clin Investig
Protein quality control (PQC) mechanisms are essential for maintaining cardiac function, and
alterations in this pathway influence multiple forms of heart disease. Since heart disease is
the leading cause of death worldwide, understanding how the delicate balance between
protein synthesis and degradation is regulated in the heart demands attention. The study by
Hu et al. reveals that the extraproteasomal ubiquitin receptor Ubiquilin1 (Ubqln1) plays an
important role in cardiac ubiquitination-proteasome coupling, particularly in response to …
Protein quality control (PQC) mechanisms are essential for maintaining cardiac function, and alterations in this pathway influence multiple forms of heart disease. Since heart disease is the leading cause of death worldwide, understanding how the delicate balance between protein synthesis and degradation is regulated in the heart demands attention. The study by Hu et al. reveals that the extraproteasomal ubiquitin receptor Ubiquilin1 (Ubqln1) plays an important role in cardiac ubiquitination-proteasome coupling, particularly in response to myocardial ischemia/reperfusion injury, thereby suggesting that this may be a new avenue for therapeutics.
The Journal of Clinical Investigation