[HTML][HTML] Identification and functional characterization of TMEM16A, a Ca2+-activated Cl− channel activated by extracellular nucleotides, in biliary epithelium
AK Dutta, A Khimji, C Kresge, A Bugde… - Journal of biological …, 2011 - ASBMB
Cl− channels in the apical membrane of biliary epithelial cells (BECs) provide the driving
force for ductular bile formation. Although a cystic fibrosis transmembrane conductance
regulator has been identified in BECs and contributes to secretion via secretin binding
basolateral receptors and increasing [cAMP] i, an alternate Cl− secretory pathway has been
identified that is activated via nucleotides (ATP, UTP) binding apical P2 receptors and
increasing [Ca 2+] i. The molecular identity of this Ca 2+-activated Cl− channel is unknown …
force for ductular bile formation. Although a cystic fibrosis transmembrane conductance
regulator has been identified in BECs and contributes to secretion via secretin binding
basolateral receptors and increasing [cAMP] i, an alternate Cl− secretory pathway has been
identified that is activated via nucleotides (ATP, UTP) binding apical P2 receptors and
increasing [Ca 2+] i. The molecular identity of this Ca 2+-activated Cl− channel is unknown …