CCK-58 prolongs the intermeal interval, whereas CCK-8 reduces this interval: not all forms of cholecystokinin have equal bioactivity
AI Sayegh, MC Washington, SJ Raboin, AH Aglan… - Peptides, 2014 - Elsevier
It has been accepted for decades that “all forms of cholecystokinin (CCK) have equal
bioactivity,” despite accumulating evidence to the contrary. To challenge this concept, we
compared two feeding responses, meal size (MS, 10% sucrose) and intermeal interval (IMI),
in response to CCK-58, which is the major endocrine form of CCK, and CCK-8, which is the
most abundantly utilized form. Doses (0, 0.1, 0.5, 0.75, 1, 3 and 5 nmol/kg) were
administered intraperitoneally over a 210-min test to Sprague Dawley rats that had been …
bioactivity,” despite accumulating evidence to the contrary. To challenge this concept, we
compared two feeding responses, meal size (MS, 10% sucrose) and intermeal interval (IMI),
in response to CCK-58, which is the major endocrine form of CCK, and CCK-8, which is the
most abundantly utilized form. Doses (0, 0.1, 0.5, 0.75, 1, 3 and 5 nmol/kg) were
administered intraperitoneally over a 210-min test to Sprague Dawley rats that had been …
