CCK-58 elicits both satiety and satiation in rats while CCK-8 elicits only satiation

J Overduin, J Gibbs, DE Cummings, JR Reeve Jr - Peptides, 2014 - Elsevier
Reduction of food intake by exogenous cholecystokinin (CCK) has been demonstrated
primarily for its short molecular form, CCK-8. Mounting evidence, however, implicates CCK-
58 as a major physiologically active CCK form, with different neural and exocrine response
profiles than CCK-8. In three studies, we compared meal-pattern effects of intraperitoneal
injections CCK-8 vs. CCK-58 in undeprived male Sprague-Dawley rats consuming
sweetened condensed milk. In study 1, rats (N= 10) received CCK-8, CCK-58 (0.45, 0.9, 1.8 …