The Mexican hairless dog as a model for assessing the comedolytic and morphogenic activity of retinoids
RM Schwartzman, AM Kligman… - British Journal of …, 1996 - Wiley Online Library
RM Schwartzman, AM Kligman, DD Duclos
British Journal of Dermatology, 1996•Wiley Online LibraryThe skin of the Mexican hairless dog is covered with comedones, and this animal therefore
provides a potentially useful model to assess the comedolytic activity of topical anti‐acne
drugs. We treated an animal with three different formulations of tretinoin for a 14‐week
period, and all produced a similar clinical response. There was a striking reduction in the
number of comedones, and the skin became lighter and more uniform in colour. Histological
changes were similar to those reported in humans treated with tretinoin, but a novel linding …
provides a potentially useful model to assess the comedolytic activity of topical anti‐acne
drugs. We treated an animal with three different formulations of tretinoin for a 14‐week
period, and all produced a similar clinical response. There was a striking reduction in the
number of comedones, and the skin became lighter and more uniform in colour. Histological
changes were similar to those reported in humans treated with tretinoin, but a novel linding …
Summary
The skin of the Mexican hairless dog is covered with comedones, and this animal therefore provides a potentially useful model to assess the comedolytic activity of topical anti‐acne drugs.
We treated an animal with three different formulations of tretinoin for a 14‐week period, and all produced a similar clinical response. There was a striking reduction in the number of comedones, and the skin became lighter and more uniform in colour. Histological changes were similar to those reported in humans treated with tretinoin, but a novel linding was incomplete neogenesis of hair follicles.
We suggest that the Mexican hairless dog may be a useful model for screening novel molecules for retinoid activity.
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