[HTML][HTML] KCNQ potassium channels modulate sensitivity of skin down-hair (D-hair) mechanoreceptors
S Schütze, IJ Orozco, TJ Jentsch - Journal of Biological Chemistry, 2016 - ASBMB
M-current-mediating KCNQ (K v 7) channels play an important role in regulating the
excitability of neuronal cells, as highlighted by mutations in Kcnq2 and Kcnq3 that underlie
certain forms of epilepsy. In addition to their expression in brain, KCNQ2 and-3 are also
found in the somatosensory system. We have now detected both KCNQ2 and KCNQ3 in a
subset of dorsal root ganglia neurons that correspond to D-hair Aδ-fibers and demonstrate
KCNQ3 expression in peripheral nerve endings of cutaneous D-hair follicles …
excitability of neuronal cells, as highlighted by mutations in Kcnq2 and Kcnq3 that underlie
certain forms of epilepsy. In addition to their expression in brain, KCNQ2 and-3 are also
found in the somatosensory system. We have now detected both KCNQ2 and KCNQ3 in a
subset of dorsal root ganglia neurons that correspond to D-hair Aδ-fibers and demonstrate
KCNQ3 expression in peripheral nerve endings of cutaneous D-hair follicles …