Novel concepts of prevention and treatment of atopic dermatitis through barrier and immune manipulations with implications for the atopic march
T Czarnowicki, JG Krueger… - Journal of Allergy and …, 2017 - Elsevier
Skin barrier abnormalities have been suggested to play an essential role in initiation of early
atopic dermatitis (AD). Antigen penetration through a compromised barrier likely leads to
increased innate immune responses, antigen-presenting cell stimulation, and priming of
overt cutaneous disease. In a TH 2-promoting environment, T-cell/B-cell interactions
occurring in regional lymph nodes lead to excessive IgE switch. Concurrent redistribution of
memory T cells into the circulation not only leads to exacerbation of AD through T-cell skin …
atopic dermatitis (AD). Antigen penetration through a compromised barrier likely leads to
increased innate immune responses, antigen-presenting cell stimulation, and priming of
overt cutaneous disease. In a TH 2-promoting environment, T-cell/B-cell interactions
occurring in regional lymph nodes lead to excessive IgE switch. Concurrent redistribution of
memory T cells into the circulation not only leads to exacerbation of AD through T-cell skin …
