[HTML][HTML] G protein-coupled receptor 40 (GPR40) and peroxisome proliferator-activated receptor γ (PPARγ): an integrated two-receptor signaling pathway
S Wang, KS Awad, JM Elinoff, EJ Dougherty… - Journal of Biological …, 2015 - ASBMB
Peroxisome proliferator-activated receptor γ (PPARγ) ligands have been widely used to treat
type 2 diabetes mellitus. However, knowledge of PPARγ signaling remains incomplete. In
addition to PPARγ, these drugs also activate G protein-coupled receptor 40 (GPR40), a Gα q-
coupled free fatty acid receptor linked to MAPK networks and glucose homeostasis. Notably,
p38 MAPK activation has been implicated in PPARγ signaling. Here, rosiglitazone (RGZ)
activation of GPR40 and p38 MAPK was found to boost PPARγ-induced gene transcription …
type 2 diabetes mellitus. However, knowledge of PPARγ signaling remains incomplete. In
addition to PPARγ, these drugs also activate G protein-coupled receptor 40 (GPR40), a Gα q-
coupled free fatty acid receptor linked to MAPK networks and glucose homeostasis. Notably,
p38 MAPK activation has been implicated in PPARγ signaling. Here, rosiglitazone (RGZ)
activation of GPR40 and p38 MAPK was found to boost PPARγ-induced gene transcription …