The enigmatic membrane fatty acid transporter CD36: New insights into fatty acid binding and their effects on uptake of oxidized LDL
AG Jay, JA Hamilton - Prostaglandins, Leukotrienes and Essential Fatty …, 2018 - Elsevier
The scavenger receptor CD36 binds numerous small biomolecules, including fatty acids,
and even large ligands such as oxidized LDL, for which it is considered a receptor. Although
CD36 has often been postulated to “transport” fatty acids across the plasma membrane, fatty
acids translocation (mass transport or kinetics) was not affected by expression of CD36 in
HEK293 cells; however, esterification of fatty acids (cellular uptake) was increased. These
recent results from our lab are consistent with the established mechanism of fatty acid entry …
and even large ligands such as oxidized LDL, for which it is considered a receptor. Although
CD36 has often been postulated to “transport” fatty acids across the plasma membrane, fatty
acids translocation (mass transport or kinetics) was not affected by expression of CD36 in
HEK293 cells; however, esterification of fatty acids (cellular uptake) was increased. These
recent results from our lab are consistent with the established mechanism of fatty acid entry …