Compstatin Cp40 blocks hematin-mediated deposition of C3b fragments on erythrocytes: Implications for treatment of malarial anemia
MA Lindorfer, EM Cook, ES Reis, D Ricklin… - Clinical …, 2016 - Elsevier
During malarial anemia, 20 uninfected red blood cells (RBCs) are destroyed for every RBC
infected by Plasmodium falciparum (Pf). Increasing evidence indicates an important role for
complement in destruction of uninfected RBCs. Products of RBC lysis induced by Pf,
including the digestive vacuole and hematin, activate complement and promote C3 fragment
deposition on uninfected RBCs. C3-opsonized cells are then subject to extravascular
destruction mediated by fixed tissue macrophages which express receptors for C3 …
infected by Plasmodium falciparum (Pf). Increasing evidence indicates an important role for
complement in destruction of uninfected RBCs. Products of RBC lysis induced by Pf,
including the digestive vacuole and hematin, activate complement and promote C3 fragment
deposition on uninfected RBCs. C3-opsonized cells are then subject to extravascular
destruction mediated by fixed tissue macrophages which express receptors for C3 …