The TH1 phenotype of follicular helper T cells indicates an IFN-γ–associated immune dysregulation in patients with CD21low common variable immunodeficiency
S Unger, M Seidl, P van Schouwenburg… - Journal of allergy and …, 2018 - Elsevier
Background A subgroup of patients with common variable immunodeficiency (CVID)
experience immune dysregulation manifesting as autoimmunity, lymphoproliferation, and
organ inflammation and thereby increasing morbidity and mortality. Therefore treatment of
these complications demands a deeper comprehension of their cause and pathophysiology.
Objectives On the basis of the identification of an interferon signature in patients with CVID
with secondary complications and a skewed follicular helper T-cell differentiation in defined …
experience immune dysregulation manifesting as autoimmunity, lymphoproliferation, and
organ inflammation and thereby increasing morbidity and mortality. Therefore treatment of
these complications demands a deeper comprehension of their cause and pathophysiology.
Objectives On the basis of the identification of an interferon signature in patients with CVID
with secondary complications and a skewed follicular helper T-cell differentiation in defined …