Multiple myeloma: diagnosis and treatment

SV Rajkumar, S Kumar - Mayo Clinic Proceedings, 2016 - Elsevier
Mayo Clinic Proceedings, 2016Elsevier
The diagnosis and treatment of multiple myeloma has changed dramatically in the past
decade. The disease definition has been updated to include highly specific biomarkers in
addition to established markers of end-organ damage. The staging system has been revised
to combine both measures of tumor burden and disease biology. Advances in therapy have
resulted in a marked improvement in overall survival. New drugs introduced in the past few
years include carfilzomib, pomalidomide, panobinostat, ixazomib, elotuzumab, and …
Abstract
The diagnosis and treatment of multiple myeloma has changed dramatically in the past decade. The disease definition has been updated to include highly specific biomarkers in addition to established markers of end-organ damage. The staging system has been revised to combine both measures of tumor burden and disease biology. Advances in therapy have resulted in a marked improvement in overall survival. New drugs introduced in the past few years include carfilzomib, pomalidomide, panobinostat, ixazomib, elotuzumab, and daratumumab. In this review, we outline the current approach to the diagnosis, prognosis, and management of multiple myeloma.
Elsevier