Bone mass measurements in men and women with chronic kidney disease
SA Jamal - Current opinion in nephrology and hypertension, 2010 - journals.lww.com
Current opinion in nephrology and hypertension, 2010•journals.lww.com
Patients with CKD suffer from fractures due to impairments in bone quantity, bone quality,
and abnormalities of neuromuscular function. The complex etiology of fractures combined
with the technical limitations of bone mineral density testing, both by dual energy X-ray
absorptiometry and by peripheral quantitative computed tomography, limits the clinical utility
of bone mass measurements for fracture prediction in CKD; this is particularly true among
patients with stages 4 and 5 CKD. As such, clinicians should not routinely order bone …
and abnormalities of neuromuscular function. The complex etiology of fractures combined
with the technical limitations of bone mineral density testing, both by dual energy X-ray
absorptiometry and by peripheral quantitative computed tomography, limits the clinical utility
of bone mass measurements for fracture prediction in CKD; this is particularly true among
patients with stages 4 and 5 CKD. As such, clinicians should not routinely order bone …
Summary
Patients with CKD suffer from fractures due to impairments in bone quantity, bone quality, and abnormalities of neuromuscular function. The complex etiology of fractures combined with the technical limitations of bone mineral density testing, both by dual energy X-ray absorptiometry and by peripheral quantitative computed tomography, limits the clinical utility of bone mass measurements for fracture prediction in CKD; this is particularly true among patients with stages 4 and 5 CKD. As such, clinicians should not routinely order bone mineral density testing in patients with CKD. Further research, to determine whether bone mineral density together with other noninvasive measures to assess bone strength can predict fracture, is needed.
Lippincott Williams & Wilkins