[HTML][HTML] Regulation of fibroblast growth factor-23 signaling by klotho
H Kurosu, Y Ogawa, M Miyoshi, M Yamamoto… - Journal of Biological …, 2006 - ASBMB
The aging suppressor gene Klotho encodes a single-pass transmembrane protein. Klotho-
deficient mice exhibit a variety of aging-like phenotypes, many of which are similar to those
observed in fibroblast growth factor-23 (FGF23)-deficient mice. To test the possibility that
Klotho and FGF23 may function in a common signal transduction pathway (s), we
investigated whether Klotho is involved in FGF signaling. Here we show that Klotho protein
directly binds to multiple FGF receptors (FGFRs). The Klotho-FGFR complex binds to FGF23 …
deficient mice exhibit a variety of aging-like phenotypes, many of which are similar to those
observed in fibroblast growth factor-23 (FGF23)-deficient mice. To test the possibility that
Klotho and FGF23 may function in a common signal transduction pathway (s), we
investigated whether Klotho is involved in FGF signaling. Here we show that Klotho protein
directly binds to multiple FGF receptors (FGFRs). The Klotho-FGFR complex binds to FGF23 …